Publications

Defining ancestry, heritability and plasticity of cellular phenotypes in somatic evolution

Schiffman JS, D’Avino AR, Prieto T, Potenski C, Fan Y, Hara T, Suvà ML, Landau DA. bioRxiv, 2022 Dec 30

A microglia-CD4+ T cell partnership generates protective anti-tumor immunity to glioblastoma

Chen D*, Varanasi SK*, Hara T, Traina K, Sun M, McDonald B, Farsakoglu Y, Clanton J, Xu S, Garcia-Rivera L, Mann TH, Du V, Chung HK, Xu Z, Tripple V, Casillas E, Ma S, O’Connor C, Yang Q, Zheng Y, Hunter T, Lemke G, Kaech SM, CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma, Immunity, 2023 Sep 12, *co-first author

The transcriptional hallmarks of intra-tumor heterogeneity across a thousand tumors

Gavish A, Tyler M, Greenwald AR, Simkin D, Tschernichovsky R, Darnell NG, Somech E, Barbolin C, Antman T, Kovarsky D, Barrett T, Castro LNG, Halder D, Chanoch-Myers R, Laffy J, Mints M, Wider A, Tal R, Spitzer A, Hara T, Raitses-Gurevich M, Stossel C, Golan T, Tirosh A, Suva ML, Puram SV, Tirosh I, Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours, Nature, 2023 May 31

Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock

Sakamoto T, Fukui Y, Kondoh Y, Honda K, Shimizu T, Hara T, Hayashi T, Saitoh Y, Murakami Y, Inoue JI, Kaneko S, Osada H, Seiki M. Commun. Biol., 2021 Oct 7;4(1):1165

Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma

Hara T*, Chanoch-Myers R*, Mathewson ND, Myskiw C, Atta L, Bussema L, Eichhorn SW, Greenwald AC, Kinker GS, Rodman C, Castro LNG, Wakimoto H, Rozenblatt-Rosen O, Zhuang X, Fan J, Hunter T, Verma IM, Wucherpfennig KW, Regev A, Suvà ML, Tirosh I. Cancer Cell, 2021 June 14; 39(6):779-792.e11, *co-first author

Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis

Mathewson ND, Ashenberg O, Tirosh I, Gritsch S, Perez EM, Marx S, Jerby-Arnon L, Chanoch-Myers R, Hara T, Richman AR, Ito Y, Pyrdol J, Friedrich M, Schumann K, Poitras MJ, Gokhale PC, Castro LNG, Shore ME, Hebert CM, Shaw B, Cahill HL, Drummond M, Zhang W, Olawoyin O, Wakimoto H, Rozenblatt-Rosen O, Brastianos PK, Liu XS, Jones PS, Cahill DP, Frosch MP, Louis DN, Freeman GJ, Ligon KL, Marson A, Chiocca EA, Reardon DA, Regev A , Suvà ML, Wucherpfennig KW. Cell, 2021 Mar 4;184(5):1281-1298.e26

An integrative model of cellular states, plasticity and genetics for glioblastoma

Neftel C*, Laffy J*, Filbin MG*, Hara T*, Shore ME, Rahme GJ, Richman AR, Silverbush D, Shaw ML, Hebert CM, Dewitt J, Gritsch S, Perez L, Castro NG, Lan X, Druck N, Rodman C, Dionne D, Kaplan A, Bertalan MS, Small J, Pelton K, Becker S, Bonal D, Nguyen QD, Servis RL, Fung JM, Mylvaganam R, Mayr L, Gojo J, Haberler C, Geyeregger R, Czech T, Slavc I, Nahed BV, Curry WT, Carter BS, Wakimoto H, Brastianos PK, Batchelor TT, Stemmer-Rachamimov A, Martinez-Lage M, Frosch MP, Stamenkovic I, Riggi N, Rheinbay E, Monje M, Rozenblatt-Rosen O, Cahill DP, Patel AP, Hunter T, Verma IM, Ligon KL, Louis DN, Regev A, Bernstein BE, Tirosh I, Suvà ML. Cell, 2019 Aug 8;178(4):835-849.e21, *co-first authors

Modeling Gliomas Using Two Recombinases

Hara T#, Verma IM. Cancer Res., 2019 Aug 1;79(15):3983-3991, #corresponding author

Heterochromatin-encoded Satellite RNAs Induce Breast Cancer via De-stabilizing DNA Replication Forks

Zhu Q, Hoong N, Aslanian A, Hara T, Benner C, Heinz S, Miga KH, Ke E, Verma S, Soroczynski J, Yates JR III, Hunter T, Verma IM. Mol. Cell, 2018 Jun 7;70(5):842-853.e7

Mint3 in bone marrow-derived cells promotes lung metastasis in breast cancer model mice

Hara T, Murakami Y, Seiki M, Sakamoto T. Biochem Biophys Res Commun., 2017 Aug 26;490(3):688-692

Control of metastatic niche formation by targeting APBA3/Mint3 in inflammatory monocytes

Hara T, Nakaoka HJ, Hayashi T, Mimura K, Hoshino D, Inoue M, Nagamura F, Murakami Y, Seiki M, Sakamoto T. Proc. Natl. Acad. Sci. USA, 2017 May 30;114(22):E4416-E4424

Mint3-mediated L1CAM expression in fibroblasts promotes cancer cell proliferation via integrin α5β1 and tumour growth

Nakaoka HJ, Tanei Z, Hara T, Weng JS, Kanamori A, Hayashi T, Sato H, Orimo A, Otsuji K, Tada K, Morikawa T, Sasaki T, Fukayama M, Seiki M, Murakami Y, Sakamoto T. Oncogenesis, 2017 May 15;6(5):e334

Mint3/Apba3 depletion ameliorates severe murine influenza pneumonia and macrophage cytokine production in response to the influenza virus

Uematsu T, Fujita T, Nakaoka HJ, Hara T, Kobayashi N, Murakami Y, Seiki M, Sakamoto T. Sci. Rep., 2016 Nov 24;6:37815

The ERK signaling target RNF126 regulates anoikis resistance in cancer cells by changing the mitochondrial metabolic flux

Yoshino S, Hara T, Nakaoka HJ, Kanamori A, Murakami Y, Seiki M, Sakamoto T. Cell Discov., 2016 Jul 26;2:16019

NECAB3 Promotes Activation of Hypoxia-inducible factor-1 during Normoxia and Enhances Tumourigenicity of Cancer Cells

Nakaoka HJ, Hara T, Yoshino S, Kanamori A, Matsui Y, Shimamura T, Sato H, Murakami Y, Seiki M, Sakamoto T. Sci. Rep., 2016 Mar 7;6:2278

Hypoxia-inducible factor 1 regulation through cross talk between mTOR and MT1-MMP

Sakamoto T, Weng JS, Hara T, Yoshino S, Kozuka-Hata H, Oyama M, Seiki M. Mol. Cell Biol., 2014 Jan;34(1):30-42

Genetic screening of new genes responsible for cellular adaptation to hypoxia using a genome-wide shRNA library

Yoshino S, Hara T, Weng JS, Takahashi Y, Seiki M, and Sakamoto T. PLoS ONE, 2012. April 16;7(4). e35590

Genetic dissection of proteolytic and non-proteolytic contributions of MT1-MMP to macrophage invasion

Hara T, Mimura K, Seiki M, Sakamoto T. Biochem. Biophys. Res. Commun., 2011 Sep 23;413(2):277-81

Deletion of the Mint3/APBA3 gene in mice abrogates macrophage functions and increases resistance to lipopolysaccharide-induced septic shock

Hara T, Mimura K, Abe T, Shioi G, Seiki M, Sakamoto T. J. Biol. Chem., 2011 Sep 16;286(37):32542-51